eLQ Version 1.00
For SFjRO :
Jean-Emmanuel Bibault & Pierre Blanchard
For SFRO :
Pr Eric Lartigau, Pr Bernard Dubray, Pr Jean Jacques Mazeron, Pr Françoise Mornex, Alain Noël, Nicolas Foray, Pr David Azria
For AFCOR :
Dr Fabrice Denis
The linear-quadratic model is used to model biological response to radiation.
Each organ is characterized by two parameters, α and β. α is the cell kill per Gy of the initial linear component and β the cell kill per Gy2 of the quadratic component of the survival curve.
α/β is inversely proportional to biological sensibility to different fractionation regimens :
- α/β > 10 Gy : biological response will not be changed by different fractionation regimen. High α/β accounts for acute effects of radiation.
- α/β < 10 Gy : biological response will be changed by different fractionation regimen. Low α/β accounts for late effects of radiation.
- Spinal cord: α/β=2,
- Lung : α/β=3,
- Liver : α/β=1,
- Kidney : α/β=3,
- Parotid gland: α/β=2,
- Nervous System : α/β=3,
- Testicle : α/β=1,
- Ovary : α/β=1,
- Eye : α/β=1,
- Bone : α/β=3,
- Cartilage : α/β=1,
- Rectum : α/β=5,
- Bladder : α/β=2.
Several factors should be considered before using the Linear Quadratic Model :
- Dose / fraction :
Must be between 1 and 6 Gy.
The linear quadratic model should not be used for hypofractionated regimen.
- Time between fractions :
Two treatment sessions should not be performed with less than 6 to 8 hours between them.
The Linear Quadratic Model should not be used for accelerated treatments.
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